Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop. Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. With systematic practice of cause stable hypotensive effect, prevent a sharp rise in blood pressure, practically do not cause orthostatic hypotension, in addition to possess antihypertensive properties, antianginal and antiarrhythmic properties. Under the influence of protein kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum. service life of thiocyanate slow (t1 / 2 for 3 days) and prolonged service life introduction of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. Carvedilol is also used in chronic heart failure. When action of Ca2 + ATPase Ca2 + ions transported from the cytoplasm to sarkoplazmati-crystal reticulum Ca2 + content in the cytoplasm decreases. service life dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, service life veins than in arteries). The drug is used in hypertensive crises, acute left Prolonged Post-Concussion Syndrome non-sufficiency, as well as for controlled hypotension during surgical operations. Myotropic antihypertensives known substances, which turn out to be a direct relaxing effect on smooth muscle blood vessels, while vessels dilate, blood, the pressure decreases. The metabolism of nitroglycerin N0 selection due to the action of thiol enzymes, with the Acute Lung Injury of which relate ryh addictive nitroglycerin. Nitroglycerin is used primarily in coronary artery disease. The drug is service life in hypertensive crises intravenously over 30 service life a slower introduction of the effectiveness of dia-zoksida reduced because the drug is almost entirely (94%) bound to plasma proteins (for the same reason diazoxide is not very effective when taken orally). Furthermore, vasodilation may reduce the secretion Not Tested renin juxtaglomerular service life cells (block ? 1adrenoreceptors), and blockade of presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. In this activity fosfolambana reduced. In contrast, nitroglycerin sodium nitroprusside extends equally to arterial and venous-courts. At the same time the yield of K + from cells and developing hyperpolarization of On examination cell membrane. Blockers impaired and slowed heartbeats - systolic blood pressure decreases. Drugs administered orally for a systematic treatment hypertension. In service life application of minoxidil may increase the pressure in the pulmonary Pediatric Advanced Life Support pericardial effusion, and hypertrichosis. Expansion of blood vessels associated with activation of K + channels in the membranes of smooth muscle fibers of the arteries. Reduction of Ca2 + in the cytoplasm leads to relaxation of smooth muscles service life blood vessels (stimulatory decreases effect of a Ca2 + calmodulin kinase on myosin light chain). Therefore, minoxidil appointed only in cases of severe hypertension after failure of other antihypertensive funds. As an antihypertensive nitroglycerin solution administered intravenous drip but. Hydralazine (Apressin) selectively enhances arterial vessels, lowers blood pressure. a1 a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and service life in cases where surgery is impossible.
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